HB-EGF, the Growth Factor that Accelerates Keratinocyte Migration, But Slows Proliferation
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چکیده
منابع مشابه
Heparin-binding EGF-like growth factor accelerates keratinocyte migration and skin wound healing.
Members of the epidermal growth factor (EGF) family are the most important growth factors involved in epithelialization during cutaneous wound healing. Heparin-binding EGF-like growth factor (HB-EGF), a member of the EGF family, is thought to play an important role in skin wound healing. To investigate the in vivo function of HB-EGF in skin wound healing, we generated keratinocyte-specific HB-E...
متن کاملThe epidermal growth factor receptor (EGFR) is an integral membrane tyrosine kinase that is activated upon binding of a family of polypeptides that includes epidermal growth factor (EGF), transforming growth factor-alpha (TGFα), amphiregulin (AR), heparin-binding EGF (HB-EGF),
The epidermal growth factor receptor (EGFR) is an integral membrane tyrosine kinase that is activated upon binding of a family of polypeptides that includes epidermal growth factor (EGF), transforming growth factor-alpha (TGFα), amphiregulin (AR), heparin-binding EGF (HB-EGF), betacellulin (BTC), and epiregulin (EPR) (reviewed by Lee et al., 1995). These ligands share a conserved, three disulfi...
متن کاملStructure and function of heparin-binding EGF-like growth factor (HB-EGF).
Heparin-binding EGF-like growth factor (HB-EGF) is a 22 kDa, O-glycosylated protein that is mitogenic for fibroblasts, smooth muscle cells (SMC) and epithelial cells. This review describes the primary structure of HB-EGF, as well as its processing. The structure of the mouse and human HB-EGF genes is also discussed. Finally, this review summarizes HB-EGF expression patterns, receptor-mediated s...
متن کاملHB-EGF promotes epithelial cell migration in eyelid development.
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that binds to and activates the EGF receptor (EGFR) and ERBB4. Here, we show that HB-EGF-EGFR signaling is involved in eyelid development. HB-EGF expression is restricted to the tip of the leading edge of the migrating epithelium during eyelid closure in late gestation mouse embryos. Both HB-EGF null...
متن کاملActivation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation.
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is a potent mitogen and chemotactic factor for fibroblasts, smooth muscle cells and keratinocytes. It is demonstrated that HB-EGF is not only a ligand for HER1, as previously reported, but for HER4 as well. HB-EGF binds to NIH 3T3 cells overexpressing either HER1 or HER4 alone, but not HER2 or HER3 alone. Binding to HER4 is ind...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2012
ISSN: 0022-202X
DOI: 10.1038/jid.2012.225